Columbia Laboratories is dedicated to patient-friendly products that deliver important treatments…and are supported by scientific evidence.
For example, CRINONE® 8% (progesterone gel) helps correct the antiestrogenic effects of clomiphene citrate (CC), and has been shown to increase implantation when added to CC+estradiol.
For more information about CRINONE, click here.
Full Prescribing Information
CRINONE is indicated for progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency.
The most common side effects of CRINONE include breast enlargement, constipation, somnolence, nausea, headache, and perineal pain. CRINONE is contraindicated in patients with active thrombophlebitis or thromboembolic disorders, or a history of hormone-associated thrombophlebitis or thomboembolic disorders, missed abortion, undiagnosed vaginal bleeding, liver dysfunction or disease, and known or suspected malignancy of the breast or genital organs.
Reference: Elkind-Hirsch KE, Phillips K, Bello SM, McNichol M, de Ziegler D. Sequential hormonal supplementation with vaginal estradiol and progesterone gel corrects the effect of clomiphene on the endometrium in oligo-ovulatory women. Hum Reprod. 2002;17:295–298.
